PRP-Platelet Rich Plasma
The use and clinical validation of PRP is still in the early stages. Results of basic science and preclinical trials have not yet been confirmed in a large scalecontrolled clinical trials. For example, clinical use of PRP for nerve injury and sports medicine has produced “Promising” but “Inconsistent” results in early trials.
A 2009 systemic review of the scientific literature stated that there are a few controlled clinical trials that has adequately evaluated the safety and efficacy of PRP Treatments and concluded that PRP is “Promising, but not proven treatment option for joint, tendon, ligament, and muscle injuries”.
Support from Doctor Allan Mishra of Stanford’s’ Menlo Clinic is helping to pioneer the use of Platelet Rich Plasma, or PRP to coax the body into healing. “The easiest way to think of how PRP works is to think of cutting yourself. The platelets stop the bleeding, but they release the Growth Factors that start the healing response” said Dr Mishra.
After drawing the patients own blood, Dr Mishra places it in a centrifuge which divided the sample into three layers, leaving the platelet rich plasma in the middle. The PRP is ready to inject back into the patients knee, elbow, or joint at a point of tear. The injections raise the concentration of Platelets to about five times normal. “That is why we put the injections right underneath where the tendon attaches,
because that’s typically where they get the problem”, said Dr Mishra. He says the evidence suggests the platelets carry Growth Factor Proteins, which in turn stimulate regeneration and repair.
Some researchers also believe the Platelets may recruit other types of cells, which can help repair the damaged tissue. “There’s a study in Japan that shows when you inject the tendon with PRP, it helps bring circulating or bone marrow derived cells to that area, and it’s like a signal fire to bring in reparative cells”, said Dr Mishra. Back on the practice field, the knee showed dramatic improvement after the PRP injections.
The Procedure of the treatment of PRP is relatively simple and can be completed within an hour. Blood is drawn from the patient (Approximately 20 cc). The blood is then transferred to a 30 cc cylinder. The doctor immediately places the blood into a centrifuge for separation, which takes approximately 8 minutes. Once the PRP is separated, it is transferred to a syringe for injection. PPP (Platelet POOR Plasma) is distinctly visible and may be used separately or mixed with the PRP.
The first steps before they begin are :
All processes are done on the premises. Occasionally, certain programs are offered at various GHT specified locations.